Protein Details: Chloride channel protein ClC-Kb

Protein ID

ICDB_Pro_0593

Protein Name

Chloride channel protein ClC-Kb

Gene Name

Clcnkb

Organism

Rattus norvegicus (Rat)

Length

687 amino acids

AlphaFoldDB

AF-P51802-F1-model_v4.pdb

Function

Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization; signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.

Sequence

MEEIVGLREGSPRKPVPLQELWRPCPRIRRNIQGSLEWLKERLFRVGEDWYFLVALGVLMALISYAMNFAIGRVVRAHKWLYREIGDGHLLRYLSWTVYPVALLSFSSGFSQSITPSSGGSGIPEVKTILTGVILEDYLDIKNFGAKVVGLSCTLATGSTIFLGKLGPFVHLSVMIAAYLGRVRTKTVGEPENKTKEMELLAAGAAVGVATVFAAPISGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFHLLAVFNSEQETITSIYKTSFPVDIPFDLPEIFFFVALGAICGILSCGYNYCQRTSLFFLKSNGFTSKLLATSKPLYSALAAVVLASITYPPGVGRFMASRLSMSEYLETLFDNNSWALMTKNSSPPWSAEPDPQNLWLEWCHPQMTVFGTLVFFLVMKFWMLILATTIPIPAGYFLPIFVYGAAIGRLFGEVLSLAFPEGIVAGGKVSPIMPGAYALAGAAAFSGAVTHTLSTALLAFEVSGQIVHALPVLMAVLAANAICQSYQPSFYDGTIIVKKLPYLPWIRGRKIGSHLVTVGHFMNCTLTTLAKDMPLEEVIKVVISTDVTQYPLVETTESQVLVGIVKRTHLVQSLHTDSASWAPGQQPCLQDILANGCPTQPVTLQLSTETSLHETHNLFELLNLQLLFVTSRGRAVGSVSWVELKKAISTLTNPPAPK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 121; /ligand="chloride" ; BINDING 259; /ligand="Ca(2+)"; BINDING 261; /ligand="Ca(2+)"; BINDING 278; /ligand="Ca(2+)"; BINDING 281; /ligand="Ca(2+)"; BINDING 426; /ligand="chloride"

Disease

Location

Expressed predominantly in the kidney. Expressed in all segments of the nephron examined; including the S2 segment and the glomerulus.

DOI ID

10.1073/pnas.91.15.6943; 10.1016/s0021-9258(17)32494-8; 10.1007/s00424-002-0819-8; 10.1007/s00418-003-0535-2

RefSeq

NP_775126.1 [P51802-1]